Human TIM-3/HAVCR2 PicoKine ELISA Kit

Human TIM-3/HAVCR2 PicoKine ELISA Kit 

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Human CellExp? TIM-3 / HAVCR2, Cynomolgus Recombinant

P1391-10
EUR 164

Human CellExp? TIM-3 / HAVCR2, Cynomolgus Recombinant

P1391-50
EUR 479

Recombinant Human TIM-3/HAVCR2 (C-Fc-Avi)

CU05-10ug 10ug
EUR 126
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human TIM-3/HAVCR2 (C-Fc-Avi)

CU05-1mg 1mg
EUR 1318
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human TIM-3/HAVCR2 (C-Fc-Avi)

CU05-500ug 500ug
EUR 963
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human TIM-3/HAVCR2 (C-Fc-Avi)

CU05-50ug 50ug
EUR 278
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Polyclonal HAVCR2 / TIM-3 Antibody (aa176-194)

APR03015G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HAVCR2 / TIM-3 (aa176-194). This antibody is tested and proven to work in the following applications:

Recombinant Cynomolgus TIM-3/HAVCR2 (N-His)

CU83-10ug 10ug
EUR 141
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Cynomolgus TIM-3/HAVCR2 (N-His)

CU83-1mg 1mg
EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Cynomolgus TIM-3/HAVCR2 (N-His)

CU83-500ug 500ug
EUR 1186
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Cynomolgus TIM-3/HAVCR2 (N-His)

CU83-50ug 50ug
EUR 303
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) ELISA Kit

RD-HAVCR2-Hu-48Tests 48 Tests
EUR 521

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) ELISA Kit

RD-HAVCR2-Hu-96Tests 96 Tests
EUR 723

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) ELISA Kit

DLR-HAVCR2-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) ELISA Kit

DLR-HAVCR2-Hu-96T 96T
EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) ELISA Kit

RDR-HAVCR2-Hu-48Tests 48 Tests
EUR 544

Human Hepatitis A Virus Cellular Receptor 2 (HAVCR2) ELISA Kit

RDR-HAVCR2-Hu-96Tests 96 Tests
EUR 756

Nori Human TIM-3 ELISA Kit

GR111040 96-well
EUR 461

HAVCR2 ELISA KIT|Human

EF005096 96 Tests
EUR 689

Human Kallikrein 3 PicoKine ELISA Kit

EK0816 96 wells
EUR 456
Description: For quantitative detection of Human Kallikrein 3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human ICAM-3 PicoKine ELISA Kit

EK0940 96 wells
EUR 425
Description: For quantitative detection of human ICAM-3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-10ug 10ug
EUR 121
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-50ug 50ug
EUR 263
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Tim-3, Human Recombinant

P1357-10
EUR 164

Tim-3, Human Recombinant

P1357-50
EUR 523

HAVCR2 ELISA Kit (Human) (OKCD01216)

OKCD01216 96 Wells
EUR 831
Description: Description of target: Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, PubMed:26492563). In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN (By similarity). Expressed on Treg cells can inhibit Th17 cell responses (PubMed:24838857). Receptor for LGALS9 (PubMed:16286920, PubMed:24337741). Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth (By similarity). However, the function as receptor for LGALS9 has been challenged (PubMed:23555261). Also reported to enhance CD8+ T-cell responses to an acute infection such as by Listeria monocytogenes (By similarity). Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF-alpha. In tumor-imfiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes (By similarity). Expressed on natural killer (NK) cells acts as a coreceptor to enhance IFN-gamma production in response to LGALS9 (PubMed:22323453). In contrast, shown to suppress NK cell-mediated cytotoxicity (PubMed:22383801). Negatively regulates NK cell function in LPS-induced endotoxic shock (By similarity).By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:Q8VIM0 (HAVR2_MOUSE)1 Publication <p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.</p> <p><a href="/manual/evidences#ECO:0000305">More…</a></p> Manual assertion inferred by curator fromiRef.20"Regulation of T cell responses by the receptor molecule Tim-3."_x005F_x005F_x000D_Gorman J.V., Colgan J.D._x005F_x005F_x000D_Immunol. Res. 59:56-65(2014) [PubMed] [Europe PMC] [Abstract]Cited for: REVIEW ON FUNCTION IN REGULATING T-CELL RESPONSES.7 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease."_x005F_x005F_x000D_Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K._x005F_x005F_x000D_Nature 415:536-541(2002) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT LEU-140, TISSUE SPECIFICITY.Ref.8"Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance."_x005F_x005F_x000D_Sanchez-Fueyo A., Tian J., Picarella D., Domenig C., Zheng X.X., Sabatos C.A., Manlongat N., Bender O., Kamradt T., Kuchroo V.K., Gutierrez-Ramos J.-C., Coyle A.J., Strom T.B._x005F_x005F_x000D_Nat. Immunol. 4:1093-1101(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.9"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity."_x005F_x005F_x000D_Zhu C., Anderson A.C., Schubart A., Xiong H., Imitola J., Khoury S.J., Zheng X.X., Strom T.B., Kuchroo V.K._x005F_x005F_x000D_Nat. Immunol. 6:1245-1252(2005) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION AS A RECEPTOR FOR LGALS9.Ref.16"Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9."_x005F_x005F_x000D_Gleason M.K., Lenvik T.R., McCullar V., Felices M., O'Brien M.S., Cooley S.A., Verneris M.R., Cichocki F., Holman C.J., Panoskaltsis-Mortari A., Niki T., Hirashima M., Blazar B.R., Miller J.S._x005F_x005F_x000D_Blood 119:3064-3072(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY.Ref.18"TIM-3 does not act as a receptor for galectin-9."_x005F_x005F_x000D_Leitner J., Rieger A., Pickl W.F., Zlabinger G., Grabmeier-Pfistershammer K., Steinberger P._x005F_x005F_x000D_PLoS Pathog. 9:E1003253-E1003253(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION AS A RECEPTOR FOR LGALS9.Ref.19"Enhanced suppressor function of TIM-3+ FoxP3+ regulatory T cells."_x005F_x005F_x000D_Gautron A.S., Dominguez-Villar M., de Marcken M., Hafler D.A._x005F_x005F_x000D_Eur. J. Immunol. 44:2703-2711(2014) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY.Ref.22"TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway."_x005F_x005F_x000D_Tomkowicz B., Walsh E., Cotty A., Verona R., Sabins N., Kaplan F., Santulli-Marotto S., Chin C.N., Mooney J., Lingham R.B., Naso M., McCabe T._x005F_x005F_x000D_PLoS ONE 10:E0140694-E0140694(2015) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH VAV1; AKT; LCP2; ZAP70; SYK; PIK3R1; FYN; SH3BP2 AND SH2D2A, MUTAGENESIS OF TYR-265 AND TYR-272. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 33 pg/mL

HAVCR2 ELISA Kit (Human) (OKBB01151)

OKBB01151 96 Wells
EUR 505
Description: Description of target: Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene. The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

HAVCR2 ELISA Kit (Human) (OKBB01549)

OKBB01549 96 Wells
EUR 570
Description: Description of target: Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene. The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

Nori Equine TIM-3 ELISA Kit

GR106517 96-well
EUR 461

Nori Canine TIM-3 ELISA Kit

GR115042 96-well
EUR 461

Human Galectin-3/LGALS3 PicoKine ELISA Kit

EK0764 96 wells
EUR 425
Description: For quantitative detection of human Galectin-3 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human PTX3/Pentraxin 3 PicoKine ELISA Kit

EK0861 96 wells
EUR 425
Description: For quantitative detection of Human PTX3 in cell culture supernates, serum, plasma(EDTA) and saliva.

Human Angiostatin K1-3 PicoKine ELISA Kit

EK0905 96 wells
EUR 486
Description: For quantitative detection of human Angiostatin K1-3 in cell culture supernates, serum and plasma(heparin, EDTA).

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-10ug 10ug
EUR 110
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-1mg 1mg
EUR 1674
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-500ug 500ug
EUR 1186
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-50ug 50ug
EUR 232
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-10ug 10ug
EUR 126
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-1mg 1mg
EUR 1877
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-500ug 500ug
EUR 1328
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-50ug 50ug
EUR 232
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-10ug 10ug
EUR 126
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-1mg 1mg
EUR 1877
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-500ug 500ug
EUR 1328
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-50ug 50ug
EUR 232
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

TIM-3 Peptide

46-495P 0.1 mg
EUR 338
Description: TIM3 / HAVCR2 Peptide

TIM-3 Antibody

8659-002mg 0.02 mg
EUR 171.82
Description: The immune checkpoint protein TIM-3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM-3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM-3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

TIM-3 Antibody

8659-01mg 0.1 mg
EUR 436.42
Description: The immune checkpoint protein TIM-3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM-3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM-3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

Tim-3 Antibody

3808-100
EUR 316

Tim-3 Antibody

3808-30T
EUR 146

Nori Human TIM-3 ELISA Kit-2 Plates

GR111040-2 2 x 96-well
EUR 832

Mouse Matrilin-3 PicoKine ELISA Kit

EK2023 96 wells
EUR 425
Description: For quantitative detection of mouse Matrilin-3 in cell culture supernates, serum and plasma (heparin, EDTA).

Human REG3A PicoKine ELISA Kit

EK1834 96 wells
EUR 425
Description: For quantitative detection of human REG3A in cell culture supernates, serum and plasma (heparin).

Human SLITRK2 PicoKine ELISA Kit

EK1867 96 wells
EUR 425
Description: For quantitative detection of human SLITRK2 in cell culture supernates, serum and plasma (heparin).

Human CLEC1B PicoKine ELISA Kit

EK1921 96 wells
EUR 425
Description: For quantitative detection of human CLEC1B in cell culture supernates, serum and plasma (heparin, EDTA).

Human CA4 PicoKine ELISA Kit

EK1939 96 wells
EUR 425
Description: For quantitative detection of human CA4 in cell culture supernates, serum and plasma (heparin, EDTA, citrate).

Human CNDP1 PicoKine ELISA Kit

EK1957 96 wells
EUR 425
Description: For quantitative detection of human CNDP1 in cell culture supernates, serum and plasma (heparin, EDTA).

Human TRAIL PicoKine ELISA Kit

EK0532 96 wells
EUR 456
Description: For quantitative detection of human TRAIL in cell culture supernates, cell lysates, serum, plasma(heparin, EDTA) and saliva.

Human uPAR PicoKine ELISA Kit

EK0536 96 wells
EUR 426
Description: For quantitative detection of human uPAR in cell culture supernates, serum, plasma(heparin, EDTA) and urine.

Human VEGF PicoKine ELISA Kit

EK0539 96 wells
EUR 425
Description: For quantitative detection of human VEGF in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Human ACE PicoKine ELISA Kit

EK0557 96 wells
EUR 507
Description: For quantitative detection of human ACE in cell culture supernates, serum, plasma(heparin) and saliva.

Human CCL1 PicoKine ELISA Kit

EK0565 96 wells
EUR 425
Description: For quantitative detection of human CCL1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human TIM-3/HAVCR2 PicoKine ELISA Kit