Description: A sandwich quantitative ELISA assay kit for detection of Human Inducible T-Cell Co Stimulator (ICOS) in samples from serum, plasma, urine, cell lysates or other biological fluids.

Description: Description of target: Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <2pg/ml

Description: Description of target: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).By similarity2 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28."_x005F_x005F_x000D_Hutloff A., Dittrich A.M., Beier K.C., Eljaschewitsch B., Kraft R., Anagnostopoulos I., Kroczek R.A._x005F_x005F_x000D_Nature 397:263-266(1999) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), PROTEIN SEQUENCE OF 192-198, FUNCTION, SUBUNIT, TISSUE SPECIFICITY.Ref.8"Induction, binding specificity and function of human ICOS."_x005F_x005F_x000D_Beier K.C., Hutloff A., Dittrich A.M., Heuck C., Rauch A., Buechner K., Ludewig B., Ochs H.D., Mages H.W., Kroczek R.A._x005F_x005F_x000D_Eur. J. Immunol. 30:3707-3717(2000) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, GLYCOSYLATION, SUBUNIT, INDUCTION, TISSUE SPECIFICITY. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 5.8 pg/mL

Description: Quantitativesandwich ELISA kit for measuring Human ICOS ligand (ICOSLG) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Description: Quantitativesandwich ELISA kit for measuring Human ICOS ligand(ICOSLG) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

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