
GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells
Background: A serious problem for the medical use of human pluripotent stem cells is the event of secure, sturdy and managed differentiation protocols. Adaptation of analysis protocols utilizing reagents designated as research-only to these that are appropriate for medical use, also known as good manufacturing follow (GMP) reagents, is an important and laborious step within the translational pipeline. Nonetheless, revealed protocols to help this course of stay very restricted.
Strategies: We tailored research-grade protocols for the derivation and differentiation of long-term neuroepithelial stem cell progenitors (lt-NES) to GMP-grade reagents and elements appropriate for medical functions. We screened the robustness of the protocol with six clinical-grade hESC traces deposited within the UK Stem Cell Financial institution.
Outcomes: Right here, we current a brand new GMP-compliant protocol to derive lt-NES, that are multipotent, bankable and karyotypically steady. This protocol resulted in sturdy and reproducible differentiation of a number of clinical-grade embryonic stem cells from which we derived lt-NES. Moreover, GMP-derived lt-NES demonstrated a excessive neurogenic potential whereas retaining the flexibility to be redirected to a number of neuronal sub-types.
Conclusions: Total, we report the feasibility of derivation and differentiation of clinical-grade embryonic stem cell traces into lt-NES beneath GMP-compliant circumstances. Our protocols may very well be used as a versatile software to hurry up translation-to-clinic of pluripotent stem cells for a wide range of neurological therapies or regenerative medication research.

Individual Reaction Mix 5 |
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G065-5 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix |
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G065-X | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 1 |
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G065-1 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 10 |
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G065-10 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 11 |
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G065-11 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 12 |
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G065-12 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 2 |
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G065-2 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 3 |
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G065-3 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 4 |
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G065-4 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 6 |
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G065-6 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 7 |
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G065-7 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 8 |
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G065-8 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 9 |
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G065-9 | ABM | 200 reactions | EUR 200.4 |
5 Component Mix |
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AOAC-MIX-1 | Scientific Laboratory Supplies | EACH | EUR 117.42 |
Volatile Organics Mix |
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60-BIG-MIX | Scientific Laboratory Supplies | 1ML | EUR 120.84 |
Semi-volatile Organics Mix |
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76-BIG-MIX | Scientific Laboratory Supplies | 1ML | EUR 150.48 |
Volatile Organics Mix (76 Components) |
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8260-BIG-MIX | Scientific Laboratory Supplies | 1ML | EUR 296.4 |
Pesticide Mix 5 Containing 14 Compounds in Acetonitrile |
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SPXPR-5 | Scientific Laboratory Supplies | 1ML | EUR 183.54 |
Canadian Pesticide Mix 5 Containing 26 Compounds |
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CAN-CAN-5 | Scientific Laboratory Supplies | 1ML | EUR 127.68 |
Volatile Organics Mix (Low Level) |
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60-BIG-MIX-200 | Scientific Laboratory Supplies | 1ML | EUR 116.28 |
Volatile Organics Mix (High Level) |
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60-BIG-MIX-2000 | Scientific Laboratory Supplies | 1ML | EUR 165.3 |
2X PCR Pre-Mix (EF) (Reaction Volume 30ul) (96 Tubes) |
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9K-002-0001 | Bio Basic | 96tubes, 96prep | EUR 373.2 |
2X PCR Pre-Mix (EF) (Reaction Volume 30ul) (576 Tubes) |
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9K-002-0002 | Bio Basic | 576tubes, 576prep | EUR 1391.1 |
Individual Standard Mix A for 3/90 and 7/91 SOW |
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CLPP-A90 | Scientific Laboratory Supplies | 1ML | EUR 102.6 |
amfiEco PCR Master Mix,8-Strip RTU(2X), for 50ul reaction |
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P0704-096 | GenDepot | 96 rxns | EUR 174 |
ICP Multi Elem (18) Std 5% HNO3 |
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ICP18-MIX-2 | Scientific Laboratory Supplies | 1L | EUR 1687.2 |
HICAL Acids Mix 5mL |
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HICAL-ACIDS-5 | Scientific Laboratory Supplies | 5ML | EUR 272.46 |
IC Multi Elem (5) Cation Std in H2O |
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ICC5-MIX-THG | Scientific Laboratory Supplies | 100ML | EUR 148.2 |
Genorise® 5 x Polymerase Mix |
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GR-108010 | Genorise Scientific | 8 x 1.5 mL | EUR 597.6 |
5 Component Mix in Dimethyl Sulfoxide |
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USP-RS-C1 | Scientific Laboratory Supplies | 1ML | EUR 41.04 |
2xEs Taq Master Mix (with Dyes) |
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W0690-5 | 101Bio | - | Ask for price |
2X Reaction Buffer |
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1068-20 | Biovision | EUR 222 |
2X Reaction Buffer |
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1068-80 | Biovision | EUR 352.8 |
Reaction Columns 2ml |
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CHR5348 | Scientific Laboratory Supplies | PK100 | EUR 175.56 |
2×Taq PCR Master Mix(with dye) |
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K1034-5 | ApexBio | 5×1 ml | EUR 142.8 |
0.2ml Individual PCR Tubes |
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PCR1178 | Scientific Laboratory Supplies | PK1000 | EUR 44.35 |
0.2ml Individual PCR Tubes |
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PCR1186 | Scientific Laboratory Supplies | PK1000 | EUR 43.66 |
Benzodiazepine (Oxazepam)-BSA Antigen (HM238) (Molar Reaction Ratio: 5:1) |
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VAng-Cr3654-1mg | Creative Biolabs | 1 mg | EUR 472.8 |
Description: Benzodiazepine (Oxazepam)-BSA Antigen, matched pairs: HM238(detection); Molar Reaction Ratio: 5:1 (Benzodiazepine:BSA); Used for Lateral Flow. |
1-Drop PCR Mix (squeeze bottle, no pipet) |
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W2599-5 | 101Bio | - | Ask for price |
RANGER Reaction Buffer, 5x |
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BIO-37114 | Bioline | 3 x 1.25ml | Ask for price |
MyFi Reaction Buffer, 5x |
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BIO-37115 | Bioline | 3 x 1.25ml | Ask for price |
amfiXpand 2x Reaction Buffer |
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P0333-001 | GenDepot | 1ml | EUR 121.2 |
amfiFusion 2x Reaction Buffer |
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P0343-001 | GenDepot | 1ml | EUR 124.8 |
Templiphi 2000 Reaction Kit |
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28964286 | Scientific Laboratory Supplies | EACH | EUR 3735.78 |
IL-8 (-5 to +5) |
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5-01377 | CHI Scientific | 4 x 5mg | Ask for price |
Pipette 10ml Individual Wrap Corning |
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4101 | Scientific Laboratory Supplies | PK200 | EUR 80.94 |
Extra T7 gRNA PCR primer mix (5 uM) |
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CAS510A-PR | SBI | 50 assays | EUR 183.6 |
Forward and Reverse UCR1 Primer Mix 5 ?M |
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LV961A-UCR1 | SBI | 50 ul | EUR 198 |
2',3',5'-triacetyl-5-Azacytidine |
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B2822-5 | Biovision | EUR 183.6 |
2',3',5'-triacetyl-5-Azacytidine |
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C4119-5 | ApexBio | 5 mg | EUR 141.6 |
Description: 2',3',5'-triacetyl-5-Azacytidine (TAC) is the lead prodrug form of 5-azacytidine which may be rapidly absorbed after oral administration [1]. 5-Azacytidine is an inhibitor of DNA methyltransferase [2]. |
Histatin 5 |
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5-01307 | CHI Scientific | 4 x 1mg | Ask for price |
Necrostatin-5 |
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1865-5 | Biovision | EUR 151.2 |
Aftin-5 |
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2575-5 | Biovision | EUR 548.4 |
CHD-5 |
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2693-5 | Biovision | EUR 183.6 |
5-Iodotubercidin |
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A3125-5 | ApexBio | 5 mg | EUR 201.6 |
Description: 5-Iodotubercidin (Itu) is a purine derivative and hence an inhibitor of adenosine kinase with an IC50 value of 26 nM [1]. Adenosine kinase is important in regulating the intracellular and extracellular concentrations of adenosine and hence diverse physiological actions of adenosine [2]. |
GNF-5 |
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B1329-5 | Biovision | EUR 170.4 |
5-ROX |
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B8212-5 | ApexBio | 5 mg | EUR 234 |
Ultra SYBR Green qPCR Master Mix (2X, with ROX I) |
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W2601-5 | 101Bio | - | Ask for price |
Hi-Fi Reaction Buffer, 5x |
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BIO-37110 | Bioline | 2 x 1.5ml | Ask for price |
MyTaq reaction Buffer Colourless, 5x |
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BIO-37111 | Bioline | 4 x 1ml | Ask for price |
MyTaq Reaction Buffer Red, 5x |
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BIO-37112 | Bioline | 4 x 1ml | Ask for price |
amfiEco Taq Reaction Buffer(2X) |
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P0703-001 | GenDepot | 1ml | EUR 100.8 |
amfiEco Taq Reaction Buffer(2X) |
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P0703-005 | GenDepot | 5ml | EUR 213.6 |
Kinase Reaction Buffer Concentrate, 60ML |
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X104-60ML | Arbor Assays | 60ML | EUR 146.4 |
Electrothermal RS600 STEM reaction block |
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HEA5500 | Scientific Laboratory Supplies | EACH | EUR 8360.76 |
Electrothermal RS1000 STEM reaction block |
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HEA5504 | Scientific Laboratory Supplies | EACH | EUR 4574.82 |
Mix 524.3 Mix B 69 Components |
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5243-VCM | Scientific Laboratory Supplies | 1ML | EUR 404.7 |
2x GoldStar Best PCR Master Mix (with Dyes), 20 ul/rxn |
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W0655-5 | 101Bio | - | Ask for price |
PCR Mix |
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L5051100 | Biochain | 2.5 ml | EUR 128.4 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
dNTP Mix |
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G010 | ABM | 250 ul 10 mM each | EUR 87.6 |
dNTP Mix |
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G128 | ABM | 500 ul 10 mM each | EUR 98.4 |
dNTP Mix |
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G129 | ABM | 1.0 ml 10 mM each | EUR 121.2 |
NTP Mix |
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G943 | ABM | 250 ul 25 mM each | EUR 93.6 |
NTP Mix |
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G944 | ABM | 500 ul 25 mM each | EUR 116.4 |
NTP Mix |
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G945 | ABM | 1.0 ml 25 mM each | EUR 156 |
dNTP Mix |
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K6011105-100 | Biochain | 100 ul (10 mM each) | EUR 103.2 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
dNTP Mix |
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K6011105-1000 | Biochain | 1000 ul (10 mM each) | EUR 241.2 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
dNTP Mix |
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K6011105-200 | Biochain | 200 ul (10 mM each) | EUR 111.6 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
dNTP Mix |
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K6011105-400 | Biochain | 400 ul (10 mM each) | EUR 139.2 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
Benzidines Mix |
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605-X-MC | Scientific Laboratory Supplies | 1ML | EUR 42.18 |
Analyte Mix |
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608-A | Scientific Laboratory Supplies | 1ML | EUR 67.26 |
Alcohols Mix |
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8015B-A | Scientific Laboratory Supplies | 1ML | EUR 44.46 |
Analyte Mix |
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8140-A | Scientific Laboratory Supplies | 1ML | EUR 165.3 |
Analyte Mix |
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8141-AB | Scientific Laboratory Supplies | 1ML | EUR 182.4 |
Analyte Mix |
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5031-A | Scientific Laboratory Supplies | 1ML | EUR 166.44 |
Analyte Mix |
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5491-A | Scientific Laboratory Supplies | 1ML | EUR 45.6 |
Phenolics Mix |
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CLPS-A | Scientific Laboratory Supplies | 1ML | EUR 46.74 |
Phenol 5 Comp Mix Std 2000ug/mL in MeOH |
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REPHE004 | Scientific Laboratory Supplies | 1ML | EUR 79.8 |
Phenol 5 Comp Mix Std 2000ug/mL in DCM |
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REPHE008 | Scientific Laboratory Supplies | 1ML | EUR 79.8 |
Phenol 5 Comp Mix Std 2000ug/mL in MeOH |
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REPHE042 | Scientific Laboratory Supplies | 1ML | EUR 80.94 |
Phenol 5 Comp Mix Std Mixed Conc in MeOH |
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REPHE044 | Scientific Laboratory Supplies | 1ML | EUR 80.94 |
Phenol 5 Comp Mix Std 2000ug/mL in DCM |
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REPHE045 | Scientific Laboratory Supplies | 1ML | EUR 80.94 |
Phenol 5 Comp Mix Std 2000ug/mL in DCM |
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REPHE046 | Scientific Laboratory Supplies | 1ML | EUR 80.94 |
VOC Std 5 Comp Mix 100ug/mL in MeOH |
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REVOC0043 | Scientific Laboratory Supplies | 1ML | EUR 115.14 |
VOC Std 5 Comp Mix Mixed Concs in MeOH |
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REVOC0044 | Scientific Laboratory Supplies | 1ML | EUR 38.76 |
VOC Std 5 Comp Mix Mixed Concs in MeOH |
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REVOC0045 | Scientific Laboratory Supplies | 1ML | EUR 62.7 |
Thrombin Receptor Activator for Peptide 5 (TRAP-5) |
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A1036-5 | ApexBio | 5 mg | EUR 122.4 |
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5),(C30H50N8O7), a peptide with the sequence NH2-Ser-Phe-Leu-Leu-Arg-COOH, MW= 634.76. coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response. |
[Cit5]-TRAP-5 |
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5-00062 | CHI Scientific | 4 x 5mg | Ask for price |
A-VI-5 |
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5-00524 | CHI Scientific | 4 x 5mg | Ask for price |
ACTH(5-10) |
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5-00605 | CHI Scientific | 4 x 5mg | Ask for price |
Dynamic Laser Speckle Imaging meets Machine Studying to allow Fast Antibacterial Susceptibility Testing (DyRAST)
Fast antibacterial susceptibility testing (RAST) strategies which measure change of a bacterial phenotype in response to a given therapy are of great significance in healthcare, as they’ll help care-givers within the well timed administration of appropriate remedies. Numerous RAST strategies have been reported for monitoring bacterial phenotypes, together with dimension, form, movement, and redox state. Nonetheless, they nonetheless require cumbersome and costly devices – which hinders their software in resource-limited environments – and/or make the most of labeling reagents which may intervene with antibiotics and add to price.
Moreover, the present RAST strategies don’t deal with the potential gradual adaptation of micro organism to antibiotics, which may result in a false prognosis. On this work, we current a RAST strategy by leveraging machine studying to research time-resolved dynamic laser speckle imaging (DLSI) outcomes. DLSI captures change of bacterial movement/division in response to antibiotic remedies.
Our technique precisely predicts the minimal inhibitory focus (MIC) of ampicillin and gentamicin for a mannequin pressure of Escherichia coli (E. coli Ok-12) in 60 minutes, in comparison with 6 hours utilizing the at the moment FDA-approved phenotype-based RAST method. Along with ampicillin (a β-lactam) and gentamicin (an aminoglycoside), we studied the impact of ceftriaxone (a third-generation medical cephalosporin) on E. coli Ok-12. The machine studying algorithm was skilled and validated utilizing the in a single day outcomes of a gold customary AST technique enabling prediction of MIC with a equally excessive accuracy, but considerably sooner.
Polymer-Supported Phosphoric, Phosphonic and Phosphinic Acids-From Synthesis to Properties and Purposes in Separation Processes
Environment friendly separation applied sciences are essential to the atmosphere and world financial system. The problem posed to scientists is how one can engineer selectivity in the direction of a focused substrate, particularly from multicomponent options. Polymer-supported reagents have gained plenty of consideration on this context, as they eradicate plenty of inconveniences regarding broadly used solvent extraction strategies.
However, the selection of an applicable ligand for immobilization could also be derived from the habits of soluble compounds beneath solvent extraction circumstances. Organophosphorus compounds play a big function in separation science and expertise. The options they possess, equivalent to variable oxidation states, multivalence, asymmetry and metal-binding properties, spotlight their standing as a novel and versatile class of compounds, able to selective separations continuing by means of completely different mechanisms.
This evaluate supplies an in depth survey of polymers containing phosphoric, phosphonic and phosphinic acid functionalities within the aspect chain and covers foremost advances within the preparation and software of those supplies in separation science, together with essentially the most related synthesis routes (Arbuzov, Perkow, Mannich, Kabachnik-Fields reactions, and many others.), in addition to the primary levels within the improvement of organophosphorus resins and a very powerful achievements within the subject.
Individual Reaction Mix 7 |
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G065-7 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 8 |
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G065-8 | ABM | 200 reactions | EUR 200.4 |
Individual Reaction Mix 9 |
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G065-9 | ABM | 200 reactions | EUR 200.4 |
Volatile Organics Mix |
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60-BIG-MIX | Scientific Laboratory Supplies | 1ML | EUR 120.84 |
5 Component Mix |
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AOAC-MIX-1 | Scientific Laboratory Supplies | EACH | EUR 117.42 |
Pesticide Mix 4 Containing 15 Compounds in Acetonitrile |
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SPXPR-4 | Scientific Laboratory Supplies | 1ML | EUR 175.56 |
Semi-volatile Organics Mix |
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76-BIG-MIX | Scientific Laboratory Supplies | 1ML | EUR 150.48 |
Canadian Pesticide Mix 4 Containing 19 Compounds |
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CAN-CAN-4 | Scientific Laboratory Supplies | 1ML | EUR 123.12 |
Volatile Organics Mix (76 Components) |
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8260-BIG-MIX | Scientific Laboratory Supplies | 1ML | EUR 296.4 |
Volatile Organics Mix (Low Level) |
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60-BIG-MIX-200 | Scientific Laboratory Supplies | 1ML | EUR 116.28 |
Volatile Organics Mix (High Level) |
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60-BIG-MIX-2000 | Scientific Laboratory Supplies | 1ML | EUR 165.3 |
2X PCR Pre-Mix (EF) (Reaction Volume 30ul) (96 Tubes) |
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9K-002-0001 | Bio Basic | 96tubes, 96prep | EUR 373.2 |
2X PCR Pre-Mix (EF) (Reaction Volume 30ul) (576 Tubes) |
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9K-002-0002 | Bio Basic | 576tubes, 576prep | EUR 1391.1 |
Individual Standard Mix A for 3/90 and 7/91 SOW |
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CLPP-A90 | Scientific Laboratory Supplies | 1ML | EUR 102.6 |
amfiEco PCR Master Mix,8-Strip RTU(2X), for 50ul reaction |
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P0704-096 | GenDepot | 96 rxns | EUR 174 |
40mM dNTP Mix (10mM/80µm each) |
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PR3040-M-4 | Benchmark Scientific | 1 PC | EUR 190.93 |
Method 524.2 Revision 4 Mix |
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5242-R4200 | Scientific Laboratory Supplies | 1ML | EUR 76.38 |
10 mM dNTP Mix of 2.5 mM 4 dNTP Mix |
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GR103045 | Genorise Scientific | 1 mL | EUR 75.6 |
2X Reaction Buffer |
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1068-20 | Biovision | EUR 222 |
2X Reaction Buffer |
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1068-80 | Biovision | EUR 352.8 |
Reaction Columns 2ml |
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CHR5348 | Scientific Laboratory Supplies | PK100 | EUR 175.56 |
IL-4 Interleukin 4 Human Recombinant Protein, Yeast |
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PROTP05112-4 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: Interleukin-4 Human Recombinant produced in yeast is a single, glycosylated polypeptide chain containing 129 amino acids.;The IL-4 is purified by proprietary chromatographic techniques. |
0.2ml Individual PCR Tubes |
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PCR1178 | Scientific Laboratory Supplies | PK1000 | EUR 44.35 |
0.2ml Individual PCR Tubes |
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PCR1186 | Scientific Laboratory Supplies | PK1000 | EUR 43.66 |
pLenti-CLDN1 shRNA-4 Plasmid |
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PVTBAV04867-4 | Lifescience Market | 2 ug | EUR 427.2 |
Feline IL-4 Recombinant Protein |
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R00230-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Feline IL-4 Recombinant Protein is purified interleukin-4 produced in yeast. |
Digital Shaker For 4 Microplates |
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6782-4 | Scientific Laboratory Supplies | EACH | EUR 1110.36 |
RANGER Reaction Buffer, 5x |
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BIO-37114 | Bioline | 3 x 1.25ml | Ask for price |
MyFi Reaction Buffer, 5x |
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BIO-37115 | Bioline | 3 x 1.25ml | Ask for price |
amfiXpand 2x Reaction Buffer |
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P0333-001 | GenDepot | 1ml | EUR 121.2 |
amfiFusion 2x Reaction Buffer |
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P0343-001 | GenDepot | 1ml | EUR 124.8 |
Templiphi 2000 Reaction Kit |
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28964286 | Scientific Laboratory Supplies | EACH | EUR 3735.78 |
Volatile Organics Combination Mix D 4 pack |
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624-DH | Scientific Laboratory Supplies | 1ML | EUR 36.48 |
Method 524.2 Revision 4 Mix (High Level) |
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5242-R4 | Scientific Laboratory Supplies | 1ML | EUR 83.22 |
DIGITAL SHAKER FOR 4 MICROPLATES, 120V |
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6780-4 | CORNING | 1/pk | EUR 957.6 |
Description: Lab Equipment; Shakers & Mixers |
Mouse FibrOut 4, for brain, neural |
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4-20507 | CHI Scientific | 1 ml | Ask for price |
Mouse FibrOut 4, for brain, neural |
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4-20508 | CHI Scientific | 5 x 1 ml | Ask for price |
Rat FibrOut 4, for brain, neural |
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4-20533 | CHI Scientific | 1 ml | Ask for price |
Rat FibrOut 4, for brain, neural |
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4-20534 | CHI Scientific | 5 x 1 ml | Ask for price |
Human FibrOut 4, for brain, neural |
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4-21552 | CHI Scientific | 1 ml | Ask for price |
Human FibrOut 4, for brain, neural |
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4-21553 | CHI Scientific | 5 x 1 ml | Ask for price |
Recombinant Human PF-4 (CXCL4) Protein |
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PROTP02776-4 | BosterBio | 20ug | EUR 380.4 |
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. |
Recombinant Human 4-1BB Receptor Protein |
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PROTQ07011-4 | BosterBio | 20ug | EUR 380.4 |
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. |
ICP-MS Multi-Element Solution 4 |
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CLMS-4 | Scientific Laboratory Supplies | 125ML | EUR 221.16 |
Pipette 10ml Individual Wrap Corning |
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4101 | Scientific Laboratory Supplies | PK200 | EUR 80.94 |
Bone Dissociation System 4 (Osteoblasts), Adult Mouse |
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4-20214 | CHI Scientific | ea | Ask for price |
Liver Dissociation System 4 (Hepatocytes, rat), Rat |
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4-20304 | CHI Scientific | ea | Ask for price |
Pituitary Dissociation System 4 (Pituitary), Adult mouse |
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4-20404 | CHI Scientific | ea | Ask for price |
Thymus Dissociation System 4 (Epithelial), Adult rat |
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4-20444 | CHI Scientific | ea | Ask for price |
Base/Neutral Surrogate Mix (4) (1000ppm) - 5.5mL Bottle |
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ECS-N-022 | Scientific Laboratory Supplies | 5.5ML | EUR 66.12 |
Acid Extractables Surrogate Mix (4) (2000ppm) - 5.5mL Bottle |
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ECS-N-023 | Scientific Laboratory Supplies | 5.5ML | EUR 98.04 |
Base/Neutral Surrogate Mix 4 component-10.5mL Bottle |
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ECS-Z-022 | Scientific Laboratory Supplies | 10.5ML | EUR 118.56 |
Acid Extractables Surrogate Mix 4 component-10.5mL Bottle |
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ECS-Z-023 | Scientific Laboratory Supplies | 10.5ML | EUR 186.96 |
DIGITAL SHAKER FOR 4 MICROPLATES, 230V-EU PLUG |
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6781-4 | CORNING | 1/pk | EUR 957.6 |
Description: Lab Equipment; Shakers & Mixers |
Cartilage Dissociation System 4 (Chondrocytes), Mouse and Rat |
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4-20234 | CHI Scientific | ea | Ask for price |
Mammary Dissociation System 4 (Epithelial, Swiss 3T3), Mouse |
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4-20324 | CHI Scientific | ea | Ask for price |
Pancreas Dissociation System 4 (Islets), Mouse and Rat |
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4-20374 | CHI Scientific | ea | Ask for price |
Skin Dissociation System 4 (Keratinocytes), Mouse and Rat |
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4-20434 | CHI Scientific | ea | Ask for price |
Hi-Fi Reaction Buffer, 5x |
|||
BIO-37110 | Bioline | 2 x 1.5ml | Ask for price |
MyTaq reaction Buffer Colourless, 5x |
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BIO-37111 | Bioline | 4 x 1ml | Ask for price |
MyTaq Reaction Buffer Red, 5x |
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BIO-37112 | Bioline | 4 x 1ml | Ask for price |
amfiEco Taq Reaction Buffer(2X) |
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P0703-001 | GenDepot | 1ml | EUR 100.8 |
amfiEco Taq Reaction Buffer(2X) |
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P0703-005 | GenDepot | 5ml | EUR 213.6 |
Kinase Reaction Buffer Concentrate, 60ML |
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X104-60ML | Arbor Assays | 60ML | EUR 146.4 |
Electrothermal RS600 STEM reaction block |
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HEA5500 | Scientific Laboratory Supplies | EACH | EUR 8360.76 |
Electrothermal RS1000 STEM reaction block |
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HEA5504 | Scientific Laboratory Supplies | EACH | EUR 4574.82 |
Mix 524.3 Mix B 69 Components |
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5243-VCM | Scientific Laboratory Supplies | 1ML | EUR 404.7 |
Adipose/Fat Dissociation System 4 (Predipocytes), Mouse and Rat |
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4-20194 | CHI Scientific | ea | Ask for price |
Brain Dissociation System 4 (Endothelial, Microvessels), Mouse and Rat |
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4-20224 | CHI Scientific | ea | Ask for price |
Endothelial Dissociation System 4 (Endothelial,Cerebral), Mouse and Rat |
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4-20244 | CHI Scientific | ea | Ask for price |
Heart Dissociation System 4 (Myocytes,Ventricles), Mouse and Rat |
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4-20274 | CHI Scientific | ea | Ask for price |
Muscle Dissociation System 4 (Smooth muscle), Mouse and Rat |
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4-20334 | CHI Scientific | ea | Ask for price |
Parotid Dissociation System 4 (Parotid acinar), Mouse and Rat |
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4-20394 | CHI Scientific | ea | Ask for price |
PCR Mix |
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L5051100 | Biochain | 2.5 ml | EUR 128.4 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
dNTP Mix |
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G010 | ABM | 250 ul 10 mM each | EUR 87.6 |
dNTP Mix |
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G128 | ABM | 500 ul 10 mM each | EUR 98.4 |
dNTP Mix |
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G129 | ABM | 1.0 ml 10 mM each | EUR 121.2 |
NTP Mix |
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G943 | ABM | 250 ul 25 mM each | EUR 93.6 |
NTP Mix |
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G944 | ABM | 500 ul 25 mM each | EUR 116.4 |
NTP Mix |
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G945 | ABM | 1.0 ml 25 mM each | EUR 156 |
dNTP Mix |
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K6011105-100 | Biochain | 100 ul (10 mM each) | EUR 103.2 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
dNTP Mix |
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K6011105-1000 | Biochain | 1000 ul (10 mM each) | EUR 241.2 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
dNTP Mix |
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K6011105-200 | Biochain | 200 ul (10 mM each) | EUR 111.6 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
dNTP Mix |
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K6011105-400 | Biochain | 400 ul (10 mM each) | EUR 139.2 |
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol. |
Benzidines Mix |
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605-X-MC | Scientific Laboratory Supplies | 1ML | EUR 42.18 |
Analyte Mix |
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608-A | Scientific Laboratory Supplies | 1ML | EUR 67.26 |
Alcohols Mix |
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8015B-A | Scientific Laboratory Supplies | 1ML | EUR 44.46 |
Analyte Mix |
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8140-A | Scientific Laboratory Supplies | 1ML | EUR 165.3 |
Analyte Mix |
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8141-AB | Scientific Laboratory Supplies | 1ML | EUR 182.4 |
Analyte Mix |
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5031-A | Scientific Laboratory Supplies | 1ML | EUR 166.44 |
Analyte Mix |
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5491-A | Scientific Laboratory Supplies | 1ML | EUR 45.6 |
Phenolics Mix |
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CLPS-A | Scientific Laboratory Supplies | 1ML | EUR 46.74 |
BD 6intransfer pipette1and2ml graduationssterile Individual wrap |
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357575 | Scientific Laboratory Supplies | PK500 | EUR 118.56 |
Epithelial Dissociation System 4 (Epithelial,Submandibular salivary), Mouse and Rat |
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4-20254 | CHI Scientific | ea | Ask for price |
Heart Dissociation System 4 (Retinal pigment epithelial), Mouse and Rat |
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4-20294 | CHI Scientific | ea | Ask for price |
Lung Dissociation System 4 (Alveolar type II), Mouse and Rat |
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4-20314 | CHI Scientific | ea | Ask for price |
Reproductive Tissue Dissociation System 4 (Epithelial, vagina), Mouse and Rat |
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4-20414 | CHI Scientific | ea | Ask for price |
ExoStd? Lyophilized Exosome Standard (30 µg, Human Plasma, 4 vials) |
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M1040-4 | Biovision | EUR 1090.8 |
ExoStd? Lyophilized Exosome Standard (100 µg, Human Plasma, 4 vials) |
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M1041-4 | Biovision | EUR 1364.4 |
ExoStd? Lyophilized Exosome Standard (30 µg, Human Serum, 4 vials) |
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M1042-4 | Biovision | EUR 1090.8 |
ExoStd? Lyophilized Exosome Standard (100 µg, Human Serum, 4 vials) |
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M1043-4 | Biovision | EUR 1358.4 |
ExoStd? Lyophilized Exosome Standard (30 µg, Human Urine, 4 vials) |
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M1044-4 | Biovision | EUR 1090.8 |
ExoStd? Lyophilized Exosome Standard (100 µg, Human Urine, 4 vials) |
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M1045-4 | Biovision | EUR 1364.4 |
ExoStd? Lyophilized Exosome Standard (30 µg, Human Saliva, 4 vials) |
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M1046-4 | Biovision | EUR 1096.8 |
ExoStd? Lyophilized Exosome Standard (100 µg, Human Saliva, 4 vials) |
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M1047-4 | Biovision | EUR 1364.4 |
ExoStd? Lyophilized Exosome Standard (30 µg, U87 MG, 4 vials) |
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M1054-4 | Biovision | EUR 1096.8 |
ExoStd? Lyophilized Exosome Standard (100 µg, U87 MG, 4 vials) |
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M1055-4 | Biovision | EUR 1370.4 |
ICP-MS Tuning Solution 4 |
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CL-TUNE-4 | Scientific Laboratory Supplies | 125ML | EUR 126.54 |
Turbidity Std Ratio 4 NTU |
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CRSR-4-500 | Scientific Laboratory Supplies | 500ML | EUR 181.26 |
Adrenal Dissociation System 4 (Heart, Adrenal chromaffin, Paraneurons), Mouse and Rat |
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4-20204 | CHI Scientific | ea | Ask for price |
Kidney Dissociation System 4 (Inner medullary duct,Papillae), Mouse and Rat |
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4-29294 | CHI Scientific | ea | Ask for price |
ExoStd? Lyophilized Exosome Standard (30 µg, COLO1 cell line, 4 vials) |
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M1048-4 | Biovision | EUR 1096.8 |
ExoStd? Lyophilized Exosome Standard (100 µg, COLO1 cell line, 4 vials) |
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M1049-4 | Biovision | EUR 1370.4 |
ExoStd? Lyophilized Exosome Standard (30 µg, MM1 cell line, 4 vials) |
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M1050-4 | Biovision | EUR 1096.8 |
ExoStd? Lyophilized Exosome Standard (100 µg, MM1 cell line, 4 vials) |
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M1051-4 | Biovision | EUR 1370.4 |
ExoStd? Lyophilized Exosome Standard (30 µg, BLCL21 cell line, 4 vials) |
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M1052-4 | Biovision | EUR 1096.8 |
ExoStd? Lyophilized Exosome Standard (100 µg, BLCL21 cell line, 4 vials) |
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M1053-4 | Biovision | EUR 1370.4 |