Human NOTCH1 PicoKine ELISA Kit

Description: Enzyme-linked immunosorbent assay kit for quantification of Human NOTCH1 in samples from serum, plasma, tissue homogenates and other biological fluids.

Description: Description of target: Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <12pg/ml

Description: Description of target: NOTCH1 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.062ng/mL

Description: Description of target: This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.055 ng/mL

Description: Description of target: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 39.4 pg/mL

Description: Description of target: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.054 ng/mL

Description: Description of target: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 49 pg/mL

Description: Rabbit polyclonal NOTCH1 antibody

Description: Affinity purified Rabbit polyclonal NOTCH1 antibody

Description: Mouse monoclonal NOTCH1 antibody

Description: Mouse monoclonal NOTCH1 antibody

Description: A polyclonal antibody against NOTCH1. Recognizes NOTCH1 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:50-1:200

Description: A polyclonal antibody against NOTCH1. Recognizes NOTCH1 from Human, Mouse, Rat, Zebrafish. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

Description: A polyclonal antibody against NOTCH1. Recognizes NOTCH1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Description: A polyclonal antibody against NOTCH1. Recognizes NOTCH1 from Human, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;ELISA:1:1000-1:2000, WB:1:200-1:1000

Description: Affinity purified rabbit polyclonal NOTCH1 antibody

Description: For quantitative detection of human ULBP1 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human ULBP3 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human Klotho in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human B2M in cell culture supernates, serum, plasma (heparin, EDTA), saliva, urine and human milk.

Description: For quantitative detection of human Haptoglobin in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human FGFBP1 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human PROS1 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human ckmm in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human ROBO1 in cell culture supernates, serum and plasma (heparin).

Description: For quantitative detection of human Ki67 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human PAM in cell culture supernates, serum and plasma (heparin, EDTA, citrate).

Description: For quantitative detection of human TINAGL1 in cell culture supernates, serum and plasma (heparin, EDTA, citrate).

Description: For quantitative detection of human CPA1 in cell culture supernates, serum and plasma (heparin, EDTA, citrate).

Description: For quantitative detection of human EphA1 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human EphA2 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human CD164 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human REG1A in cell culture supernates, serum and plasma (heparin).

Description: For quantitative detection of human CES1 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human CES2 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human REG3A in cell culture supernates, serum and plasma (heparin).

Description: For quantitative detection of human LYPD3 in cell culture supernates, serum and plasma (heparin, EDTA, citrate).

Description: For quantitative detection of human MANF in cell culture supernates, serum and plasma (heparin, EDTA).