Human NOTCH1 PicoKine ELISA Kit

Description: Description of target: NOTCH1 is a member of the Notch family. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: < 0.062ng/mL

Description: Description of target: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.054 ng/mL

Description: Description of target: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 39.4 pg/mL

Description: For quantitative detection of human ANG in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human BDNF in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA, citrate).

Description: For quantitative detection of human EGF in cell culture supernates, serum, plasma(heparin, EDTA, citrate) and urine.

Description: For quantitative detection of human EGFR in cell culture supernates, serum, plasma(heparin, EDTA) and human milk.

Description: For quantitative detection of human Eotaxin in cell culture supernates, serum and plasma(citrate, EDTA).

Description: For quantitative detection of human EPO in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human FAS in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Description: For quantitative detection of human FASL in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Description: For quantitative detection of human FGF1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human FGF2 in cell culture supernates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human FGF4 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human FGF9 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human Fibronectin in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Description: For quantitative detection of human GDNF in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human HGF in cell culture supernates, serum and plasma(EDTA, citrate).

Description: For quantitative detection of human IGFBP2 in cell culture supernates, serum, plasma (heparin, EDTA) and urine.

Description: For quantitative detection of human IGFBP4 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human IL1R1 in cell culture supernates and serum.

Description: For quantitative detection of human IL1R2 in cell culture supernates and serum.

Description: For quantitative detection of human LAMA1 in cell culture supernates, cell lysates and serum.

Description: For quantitative detection of human Leptin in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human MMP13 in cell culture supernates, serum and plasma( heparin).

Description: For quantitative detection of human OPG in cell culture supernates, serum, plasma(heparin, EDTA), saliva and urine.

Description: For quantitative detection of human OPN in cell culture supernates, serum, plasma(heparin, EDTA), human milk and urine.

Description: For quantitative detection of human PLGF in cell culture supernates, serum, plasma(heparin, EDTA, citrate) and urine.

Description: For quantitative detection of human Rantes in cell culture supernates, serum, plasma(heparin, EDTA, citrate) and urine.

Description: For quantitative detection of human SCF in cell culture supernates, serum and plasma (heparin, EDTA, citrate).

Description: For quantitative detection of human TIE2 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human TRAIL in cell culture supernates, cell lysates, serum, plasma(heparin, EDTA) and saliva.

Description: For quantitative detection of human uPAR in cell culture supernates, serum, plasma(heparin, EDTA) and urine.

Description: For quantitative detection of human VEGF in cell culture supernates, serum and plasma(heparin, EDTA, citrate).

Description: For quantitative detection of human ACE in cell culture supernates, serum, plasma(heparin) and saliva.

Description: For quantitative detection of human CCL1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human soluble CD40L in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human Resistin in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human Prolactin in cell culture supernates, serum and plasma(heparin, citrate).

Description: For quantitative detection of human Adiponectin in cell culture supernates, serum, plasma(heparin, EDTA)and urine.

Description: For quantitative detection of human Survivin in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Description: For quantitative detection of human TSP2 in cell culture supernates, serum, plasma(heparin, EDTA) and human milk.